Atherosclerosis is a chronic inflammatory disease, which is an abnormal reaction of vascular wall to various injuries. It has the characteristics of classic inflammatory degeneration, exudation and proliferation. According to the lipid metabolism of animals and the ease of operation, it is ideal to select rats as experimental animals to establish atherosclerosis models. In the modeling process, we can consider various factors that affect the formation of atherosclerosis, such as giving high-fat feed, adding sodium cholate, propylthiouracil, etc. to promote lipid absorption, gavage vitamin D3 to promote calcification, and using vaccines to form inflammatory reactions, so as to find a fast, convenient and effective model building method.

Observation indicators

Weight, blood lipids, aortic imaging examination, aortic pathology examination, etc.

Partial experimental diagram display